The Company’s work in protein misfolding could result in therapies to treat several neurodegenerative diseases, including AL (primary) and AA (secondary) forms of amyloidosis (NEOD001), Parkinson's disease and related synucleinopathies (PRX002). Prothena’s novel cell adhesion development activities could generate new therapies to treat inflammatory diseases and metastatic cancers (PRX003). Our strategy is to identify antibody candidates for clinical development by applying Prothena’s extensive expertise in generating novel therapeutic antibodies and working with collaborators having expertise in specific animal models of disease. Our lead program, NEOD001, is in Phase 1, and we anticipate moving one or more of our product candidates into clinical development each year in 2014 and 2015.
Prothena has attracted an elite team with a recognized track record both for profound scientific discoveries and for the development of therapeutics that have become leading commercial products in their respective therapeutic categories. The team brings this heritage to Prothena with the vision of continuing to create and develop novel antibody-based therapies that benefit a diverse population of patients. We also have assembled a globally recognized Scientific Advisory Board with a broad spectrum of academic and industry experience in the fields of neuroscience and immunotherapy.
Prior to December 2012, the Prothena Business operated as part of Elan Corporation, plc (Elan), not as a separate stand-alone entity. Prothena’s business consists of a substantial portion of Elan’s former drug discovery business platform, including Neotope Biosciences Limited and Onclave Therapeutics Limited, each former wholly owned subsidiaries of Elan. After the separation from Elan and the related distribution of our ordinary shares to Elan’s stockholders, our ordinary shares began trading on The NASDAQ Global Market under the symbol “PRTA” on December 21, 2012.