Select Publications from Prothena Team

• Axonopathy in an a-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation Q2 of C-Terminal-Truncated a-Synuclein. Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E Journal of American Pathology 2013 (in press)
• Vascular Alterations in PDAPP Mice Following Anti-Aβ Immunotherapy: Implications for Amyloid-Related Imaging Abnormalities (ARIA). Zago W, Schroeter S, Guido T, Khan K, Seubert P, Yednock T, Schenk D, Gregg KM, Games D, Bard F, Kinney GG. Alzheimer's & Dementia 2013 (in press)
• AL Amyloid Imaging and Therapy with a Monoclonal Antibody to a Cryptic Epitope on Amyloid Fibrils Wall. JS, Kennel SJ, Williams A, Richey T, Stuckey A, Huang Y, Macy S, Donnell R, Barbour R, Seubert P, Schenk D. PLoS ONE 7(12):e52686 (2012).
• Neutralization of soluble synaptotoxic Aß species by antibodies is epitope specific. W. Zago, M. Buttini, T.A. Comery, C. Nishioka, P. Seubert, D. Games, F. Bard, D. Schenk, G.G. Kinney . Journal of Neuroscience, 32:2696-2702 (2012).
• Sustained levels of antibodies against Aß in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice. F. Bard, M. Fox, S. Friedrich, P. Seubert, D. Schenk, G.G. Kinney, T. Yednock . Exp Neurol., 238:38-43 (2012).
• Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. K. Flanagan, K. Fitzgerald, J. Baker, K. Regnstrom, S. Gardai, F. Bard, S. Mocci, P. Seto, M. You, C. Larochelle, A. Prat, S. Chow, L. Li, C. Vandevert, W. Zago, C. Lorenzana, C. Nishioka, J. Hoffman, R. Botelho, C. Willits, K. Tanaka, J. Johnston, T. Yednock. PLoS ONE, 7(7): (2012)
• Generation and Characterization of anti-AA Amyloid-Specific Monoclonal Antibodies. J.S. Wall, S.J. Kennel, T. Richey, A. Allen, A. Stuckey, D.T. Weiss, R. Barbour, P. Seubert, A. Solomon, and D. Schenk. Frontiers of Immunology.
• Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease. E. Masliah, E. Rockenstein, M. Mante, L. Crews, B. Spencer, A. Adame, C. Patrick, M. Trejo, K. Ubhi, T. Rohn, S. Mueller-Steiner, P. Seubert, R. Barbour, L. McConlogue, M. Buttini, D. Games, D. Schenk. PLoS ONE 6 (4), 1-17 (2011)
• Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease. Guriqbal S. Basi, Hadar Feinberg, Farshid Oshidari, John Anderson, Robin Barbour, Jeanne Baker, Thomas A. Comery, Linnea Diep, Davinder Gill, Kelly Johnson-Wood, Amita Goel, Katerina Grantcharova, Mike Lee, Jingzhi Li, Anthony Partridge, Irene Griswold-Prenner, Nicolas Piot, Don Walker, Angela Widom, Menelas N. Pangalos, Peter Seubert, J. Steven Jacobsen, Dale Schenk, and William I. Weis. Journal of Biological Chemistry 285(5):3417-3427 (2010)
• Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease.
  E. Masliah, E. Rockenstein, A. Adame, M. Alford, L. Crews, M. Hashimoto, P. Seubert, M. Lee, J. Goldstein, T. Chilcote, D. Games, D. Schenk. Neuron 46, 857-868 (2005)
• Aβ42 Immunization in Alzheimer’s Disease Generates Aβ N-Terminal Antibodies.
  M. Lee, F. Bard, K. Johnson-Wood, C. Lee, K. Hu, S. Griffith, R. Black, D. Schenk, P. Seubert. Ann. Neurol. 58, 430-435 (2005)
• Peripherally administered antibodies against Amyloid β-peptide enter the centeral nervous system and reduce pathology in a mouse model of Alzheimer disease. F. Bard, C. Cannon, R. Barbour, R. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, I. Lieberburg, R. Motter, M. Nguyen, F. Soriano, N. Vasquez, K. Weiss, B. Welch, P. Seubert, D. Schenk, and T. Yednock. Nature Medicine 6(8), 916-919 (2000)
• Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. D. Schenk, R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, D. Kholodenko, M. Lee, Z. Liao, I. Lieberburg, R. Motter, L. Mutter, F. Soriano, G. Shopp, N. Vazquez, C. Vendevert, S. Walker, M. Wogulis, T. Yednock, D. Games, P. Seubert. Nature, 400, 173-177 (1999)